CovidSeniorV1, Main, Exploration, bibRecord, 000289

Real-time diagnosis of reactive oxygen species (ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic.

Identifieur interne : 000289 ( Main/Exploration ); précédent : 000288; suivant : 000290

Real-time diagnosis of reactive oxygen species (ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic.

Auteurs : Zohreh Sadat Miripour [Iran] ; Ramin Sarrami-Forooshani [Iran] ; Hassan Sanati [Iran] ; Jalil Makarem [Iran] ; Morteza Sanei Taheri [Iran] ; Fatemeh Shojaeian [Iran] ; Aida Hasanzadeh Eskafi [Iran] ; Fereshteh Abbasvandi [Iran] ; Naser Namdar [Iran] ; Hadi Ghafari [Iran] ; Parisa Aghaee [Iran] ; Ashkan Zandi [Iran] ; Mahsa Faramarzpour [Iran] ; Meisam Hoseinyazdi [Iran] ; Mahtab Tayebi [Iran] ; Mohammad Abdolahad [Iran]

Source :

Biosensors & bioelectronics [ 1873-4235 ] ; 2020.

RBID : pubmed:32729548

Descripteurs français

KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Betacoronavirus (isolement et purification), Conception d'appareillage (MeSH), Diagnostic précoce (MeSH), Espèces réactives de l'oxygène (analyse), Expectoration (composition chimique), Expectoration (virologie), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Jeune adulte (MeSH), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (diagnostic), Pneumopathie virale (virologie), Poumon (composition chimique), Poumon (virologie), Sensibilité et spécificité (MeSH), Sujet âgé (MeSH), Techniques de biocapteur (instrumentation), Techniques de biocapteur (méthodes), Techniques électrochimiques (instrumentation), Techniques électrochimiques (méthodes).
MESH :
- analyse : Espèces réactives de l'oxygène.
- composition chimique : Expectoration, Poumon.
- diagnostic : Infections à coronavirus, Pneumopathie virale.
- isolement et purification : Betacoronavirus.
- méthodes : Techniques de biocapteur, Techniques électrochimiques.
- virologie : Expectoration, Infections à coronavirus, Pneumopathie virale, Poumon.
- instrumentation : Adulte, Adulte d'âge moyen, Conception d'appareillage, Diagnostic précoce, Femelle, Humains, Jeune adulte, Mâle, Pandémies, Sensibilité et spécificité, Sujet âgé, Techniques de biocapteur, Techniques électrochimiques.

English descriptors

KwdEn :
- Adult (MeSH), Aged (MeSH), Betacoronavirus (isolation & purification), Biosensing Techniques (instrumentation), Biosensing Techniques (methods), Coronavirus Infections (diagnosis), Coronavirus Infections (virology), Early Diagnosis (MeSH), Electrochemical Techniques (instrumentation), Electrochemical Techniques (methods), Equipment Design (MeSH), Female (MeSH), Humans (MeSH), Lung (chemistry), Lung (virology), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (diagnosis), Pneumonia, Viral (virology), Reactive Oxygen Species (analysis), Sensitivity and Specificity (MeSH), Sputum (chemistry), Sputum (virology), Young Adult (MeSH).
MESH :
- chemical , analysis : Reactive Oxygen Species.
- chemistry : Lung, Sputum.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- instrumentation : Biosensing Techniques, Electrochemical Techniques.
- isolation & purification : Betacoronavirus.
- methods : Biosensing Techniques, Electrochemical Techniques.
- virology : Coronavirus Infections, Lung, Pneumonia, Viral, Sputum.
- Adult, Aged, Early Diagnosis, Equipment Design, Female, Humans, Male, Middle Aged, Pandemics, Sensitivity and Specificity, Young Adult.

Abstract

COVID-19 is the shocking viral pandemics of this year which affected the health, economy, communications, and all aspects of social activities all over the world. Early diagnosis of this viral disease is very important since it can prevent lots of mortalities and care consumption. The functional similarities between COVID-19 and COVID-2 in inducing acute respiratory syndrome lightened our mind to find a diagnostic mechanism based on early traces of mitochondrial ROS overproduction as lung cells' dysfunctions induced by the virus. We designed a simple electrochemical sensor to selectively detect the intensity of ROS in the sputum sample (with a volume of less than 500 μl). Comparing the results of the sensor with clinical diagnostics of more than 140 normal and involved cases resulted in a response calibration with accuracy and sensitivity both 97%. Testing the sensor in more than 4 hospitals shed promising lights in ROS based real-time tracing of COVID-19 from the sputum sample.

DOI: 10.1016/j.bios.2020.112435
PubMed: 32729548
PubMed Central: PMC7341050

Affiliations:

Iran

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000926
to stream Main, to step Curation: 000926

Le document en format XML

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<author><name sortKey="Makarem, Jalil" sort="Makarem, Jalil" uniqKey="Makarem J" first="Jalil" last="Makarem">Jalil Makarem</name>
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<author><name sortKey="Taheri, Morteza Sanei" sort="Taheri, Morteza Sanei" uniqKey="Taheri M" first="Morteza Sanei" last="Taheri">Morteza Sanei Taheri</name>
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<author><name sortKey="Shojaeian, Fatemeh" sort="Shojaeian, Fatemeh" uniqKey="Shojaeian F" first="Fatemeh" last="Shojaeian">Fatemeh Shojaeian</name>
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<author><name sortKey="Eskafi, Aida Hasanzadeh" sort="Eskafi, Aida Hasanzadeh" uniqKey="Eskafi A" first="Aida Hasanzadeh" last="Eskafi">Aida Hasanzadeh Eskafi</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Center, Biotechnology Department, Venom & Biotherapeutics Molecules Lab., Pasteur Institute of Iran, P.O. BOX: 131694-3551, Tehran, Iran.</nlm:affiliation>
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<author><name sortKey="Abbasvandi, Fereshteh" sort="Abbasvandi, Fereshteh" uniqKey="Abbasvandi F" first="Fereshteh" last="Abbasvandi">Fereshteh Abbasvandi</name>
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<author><name sortKey="Namdar, Naser" sort="Namdar, Naser" uniqKey="Namdar N" first="Naser" last="Namdar">Naser Namdar</name>
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<author><name sortKey="Ghafari, Hadi" sort="Ghafari, Hadi" uniqKey="Ghafari H" first="Hadi" last="Ghafari">Hadi Ghafari</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
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<author><name sortKey="Aghaee, Parisa" sort="Aghaee, Parisa" uniqKey="Aghaee P" first="Parisa" last="Aghaee">Parisa Aghaee</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
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<author><name sortKey="Zandi, Ashkan" sort="Zandi, Ashkan" uniqKey="Zandi A" first="Ashkan" last="Zandi">Ashkan Zandi</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Faramarzpour, Mahsa" sort="Faramarzpour, Mahsa" uniqKey="Faramarzpour M" first="Mahsa" last="Faramarzpour">Mahsa Faramarzpour</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
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<author><name sortKey="Hoseinyazdi, Meisam" sort="Hoseinyazdi, Meisam" uniqKey="Hoseinyazdi M" first="Meisam" last="Hoseinyazdi">Meisam Hoseinyazdi</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Medicine, Shiraz University of Medical Sciences, P.O. BOX: 71348-14336, Shiraz, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>School of Medicine, Shiraz University of Medical Sciences, P.O. BOX: 71348-14336, Shiraz</wicri:regionArea>
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<author><name sortKey="Tayebi, Mahtab" sort="Tayebi, Mahtab" uniqKey="Tayebi M" first="Mahtab" last="Tayebi">Mahtab Tayebi</name>
<affiliation wicri:level="1"><nlm:affiliation>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.</nlm:affiliation>
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<wicri:regionArea>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abdolahad, Mohammad" sort="Abdolahad, Mohammad" uniqKey="Abdolahad M" first="Mohammad" last="Abdolahad">Mohammad Abdolahad</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran. Electronic address: m.abdolahad@ut.ac.ir.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Real-time diagnosis of reactive oxygen species (ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic.</title>
<author><name sortKey="Miripour, Zohreh Sadat" sort="Miripour, Zohreh Sadat" uniqKey="Miripour Z" first="Zohreh Sadat" last="Miripour">Zohreh Sadat Miripour</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sarrami Forooshani, Ramin" sort="Sarrami Forooshani, Ramin" uniqKey="Sarrami Forooshani R" first="Ramin" last="Sarrami-Forooshani">Ramin Sarrami-Forooshani</name>
<affiliation wicri:level="1"><nlm:affiliation>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanati, Hassan" sort="Sanati, Hassan" uniqKey="Sanati H" first="Hassan" last="Sanati">Hassan Sanati</name>
<affiliation wicri:level="1"><nlm:affiliation>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Makarem, Jalil" sort="Makarem, Jalil" uniqKey="Makarem J" first="Jalil" last="Makarem">Jalil Makarem</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesia, Imam Khomeini Hospital, Tehran University of Medical Sciences, P.O. BOX: 1417653761, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Department of Anesthesia, Imam Khomeini Hospital, Tehran University of Medical Sciences, P.O. BOX: 1417653761, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Taheri, Morteza Sanei" sort="Taheri, Morteza Sanei" uniqKey="Taheri M" first="Morteza Sanei" last="Taheri">Morteza Sanei Taheri</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, P.O. BOX: 1445613131, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Department of Radiology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, P.O. BOX: 1445613131, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shojaeian, Fatemeh" sort="Shojaeian, Fatemeh" uniqKey="Shojaeian F" first="Fatemeh" last="Shojaeian">Fatemeh Shojaeian</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Medicine, Shahid Beheshti University of Medical Sciences, P.O. BOX: 1985717443, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>School of Medicine, Shahid Beheshti University of Medical Sciences, P.O. BOX: 1985717443, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Eskafi, Aida Hasanzadeh" sort="Eskafi, Aida Hasanzadeh" uniqKey="Eskafi A" first="Aida Hasanzadeh" last="Eskafi">Aida Hasanzadeh Eskafi</name>
<affiliation wicri:level="1"><nlm:affiliation>Biotechnology Research Center, Biotechnology Department, Venom & Biotherapeutics Molecules Lab., Pasteur Institute of Iran, P.O. BOX: 131694-3551, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Biotechnology Research Center, Biotechnology Department, Venom & Biotherapeutics Molecules Lab., Pasteur Institute of Iran, P.O. BOX: 131694-3551, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abbasvandi, Fereshteh" sort="Abbasvandi, Fereshteh" uniqKey="Abbasvandi F" first="Fereshteh" last="Abbasvandi">Fereshteh Abbasvandi</name>
<affiliation wicri:level="1"><nlm:affiliation>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Namdar, Naser" sort="Namdar, Naser" uniqKey="Namdar N" first="Naser" last="Namdar">Naser Namdar</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghafari, Hadi" sort="Ghafari, Hadi" uniqKey="Ghafari H" first="Hadi" last="Ghafari">Hadi Ghafari</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aghaee, Parisa" sort="Aghaee, Parisa" uniqKey="Aghaee P" first="Parisa" last="Aghaee">Parisa Aghaee</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zandi, Ashkan" sort="Zandi, Ashkan" uniqKey="Zandi A" first="Ashkan" last="Zandi">Ashkan Zandi</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Faramarzpour, Mahsa" sort="Faramarzpour, Mahsa" uniqKey="Faramarzpour M" first="Mahsa" last="Faramarzpour">Mahsa Faramarzpour</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran</wicri:regionArea>
<wicri:noRegion>Tehran</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hoseinyazdi, Meisam" sort="Hoseinyazdi, Meisam" uniqKey="Hoseinyazdi M" first="Meisam" last="Hoseinyazdi">Meisam Hoseinyazdi</name>
<affiliation wicri:level="1"><nlm:affiliation>School of Medicine, Shiraz University of Medical Sciences, P.O. BOX: 71348-14336, Shiraz, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>School of Medicine, Shiraz University of Medical Sciences, P.O. BOX: 71348-14336, Shiraz</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Tayebi, Mahtab" sort="Tayebi, Mahtab" uniqKey="Tayebi M" first="Mahtab" last="Tayebi">Mahtab Tayebi</name>
<affiliation wicri:level="1"><nlm:affiliation>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.</nlm:affiliation>
<country xml:lang="fr">Iran</country>
<wicri:regionArea>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Abdolahad, Mohammad" sort="Abdolahad, Mohammad" uniqKey="Abdolahad M" first="Mohammad" last="Abdolahad">Mohammad Abdolahad</name>
<affiliation wicri:level="1"><nlm:affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran. Electronic address: m.abdolahad@ut.ac.ir.</nlm:affiliation>
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<series><title level="j">Biosensors & bioelectronics</title>
<idno type="eISSN">1873-4235</idno>
<imprint><date when="2020" type="published">2020</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Betacoronavirus (isolation & purification)</term>
<term>Biosensing Techniques (instrumentation)</term>
<term>Biosensing Techniques (methods)</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (virology)</term>
<term>Early Diagnosis (MeSH)</term>
<term>Electrochemical Techniques (instrumentation)</term>
<term>Electrochemical Techniques (methods)</term>
<term>Equipment Design (MeSH)</term>
<term>Female (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Lung (chemistry)</term>
<term>Lung (virology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (diagnosis)</term>
<term>Pneumonia, Viral (virology)</term>
<term>Reactive Oxygen Species (analysis)</term>
<term>Sensitivity and Specificity (MeSH)</term>
<term>Sputum (chemistry)</term>
<term>Sputum (virology)</term>
<term>Young Adult (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Betacoronavirus (isolement et purification)</term>
<term>Conception d'appareillage (MeSH)</term>
<term>Diagnostic précoce (MeSH)</term>
<term>Espèces réactives de l'oxygène (analyse)</term>
<term>Expectoration (composition chimique)</term>
<term>Expectoration (virologie)</term>
<term>Femelle (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (virologie)</term>
<term>Jeune adulte (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (diagnostic)</term>
<term>Pneumopathie virale (virologie)</term>
<term>Poumon (composition chimique)</term>
<term>Poumon (virologie)</term>
<term>Sensibilité et spécificité (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Techniques de biocapteur (instrumentation)</term>
<term>Techniques de biocapteur (méthodes)</term>
<term>Techniques électrochimiques (instrumentation)</term>
<term>Techniques électrochimiques (méthodes)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Reactive Oxygen Species</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Espèces réactives de l'oxygène</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lung</term>
<term>Sputum</term>
</keywords>
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<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Biosensing Techniques</term>
<term>Electrochemical Techniques</term>
</keywords>
<keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Betacoronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Biosensing Techniques</term>
<term>Electrochemical Techniques</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Techniques de biocapteur</term>
<term>Techniques électrochimiques</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Expectoration</term>
<term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Lung</term>
<term>Pneumonia, Viral</term>
<term>Sputum</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Early Diagnosis</term>
<term>Equipment Design</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pandemics</term>
<term>Sensitivity and Specificity</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Conception d'appareillage</term>
<term>Diagnostic précoce</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Sensibilité et spécificité</term>
<term>Sujet âgé</term>
<term>Techniques de biocapteur</term>
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<front><div type="abstract" xml:lang="en">COVID-19 is the shocking viral pandemics of this year which affected the health, economy, communications, and all aspects of social activities all over the world. Early diagnosis of this viral disease is very important since it can prevent lots of mortalities and care consumption. The functional similarities between COVID-19 and COVID-2 in inducing acute respiratory syndrome lightened our mind to find a diagnostic mechanism based on early traces of mitochondrial ROS overproduction as lung cells' dysfunctions induced by the virus. We designed a simple electrochemical sensor to selectively detect the intensity of ROS in the sputum sample (with a volume of less than 500 μl). Comparing the results of the sensor with clinical diagnostics of more than 140 normal and involved cases resulted in a response calibration with accuracy and sensitivity both 97%. Testing the sensor in more than 4 hospitals shed promising lights in ROS based real-time tracing of COVID-19 from the sputum sample.</div>
</front>
</TEI>
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<DateCompleted><Year>2020</Year>
<Month>09</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-4235</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>165</Volume>
<PubDate><Year>2020</Year>
<Month>Oct</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>Biosensors & bioelectronics</Title>
<ISOAbbreviation>Biosens Bioelectron</ISOAbbreviation>
</Journal>
<ArticleTitle>Real-time diagnosis of reactive oxygen species (ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic.</ArticleTitle>
<Pagination><MedlinePgn>112435</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0956-5663(20)30429-2</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bios.2020.112435</ELocationID>
<Abstract><AbstractText>COVID-19 is the shocking viral pandemics of this year which affected the health, economy, communications, and all aspects of social activities all over the world. Early diagnosis of this viral disease is very important since it can prevent lots of mortalities and care consumption. The functional similarities between COVID-19 and COVID-2 in inducing acute respiratory syndrome lightened our mind to find a diagnostic mechanism based on early traces of mitochondrial ROS overproduction as lung cells' dysfunctions induced by the virus. We designed a simple electrochemical sensor to selectively detect the intensity of ROS in the sputum sample (with a volume of less than 500 μl). Comparing the results of the sensor with clinical diagnostics of more than 140 normal and involved cases resulted in a response calibration with accuracy and sensitivity both 97%. Testing the sensor in more than 4 hospitals shed promising lights in ROS based real-time tracing of COVID-19 from the sputum sample.</AbstractText>
<CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Miripour</LastName>
<ForeName>Zohreh Sadat</ForeName>
<Initials>ZS</Initials>
<AffiliationInfo><Affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sarrami-Forooshani</LastName>
<ForeName>Ramin</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sanati</LastName>
<ForeName>Hassan</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Makarem</LastName>
<ForeName>Jalil</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Anesthesia, Imam Khomeini Hospital, Tehran University of Medical Sciences, P.O. BOX: 1417653761, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Taheri</LastName>
<ForeName>Morteza Sanei</ForeName>
<Initials>MS</Initials>
<AffiliationInfo><Affiliation>Department of Radiology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, P.O. BOX: 1445613131, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shojaeian</LastName>
<ForeName>Fatemeh</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>School of Medicine, Shahid Beheshti University of Medical Sciences, P.O. BOX: 1985717443, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eskafi</LastName>
<ForeName>Aida Hasanzadeh</ForeName>
<Initials>AH</Initials>
<AffiliationInfo><Affiliation>Biotechnology Research Center, Biotechnology Department, Venom & Biotherapeutics Molecules Lab., Pasteur Institute of Iran, P.O. BOX: 131694-3551, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abbasvandi</LastName>
<ForeName>Fereshteh</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Namdar</LastName>
<ForeName>Naser</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ghafari</LastName>
<ForeName>Hadi</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aghaee</LastName>
<ForeName>Parisa</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zandi</LastName>
<ForeName>Ashkan</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Faramarzpour</LastName>
<ForeName>Mahsa</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hoseinyazdi</LastName>
<ForeName>Meisam</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>School of Medicine, Shiraz University of Medical Sciences, P.O. BOX: 71348-14336, Shiraz, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tayebi</LastName>
<ForeName>Mahtab</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P.O. BOX: 15179/64311, Tehran, Iran.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abdolahad</LastName>
<ForeName>Mohammad</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box: 14395/515, Tehran, Iran. Electronic address: m.abdolahad@ut.ac.ir.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>07</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Biosens Bioelectron</MedlineTA>
<NlmUniqueID>9001289</NlmUniqueID>
<ISSNLinking>0956-5663</ISSNLinking>
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</ChemicalList>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
</MeshHeading>
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<Keyword MajorTopicYN="N">Sputum</Keyword>
<Keyword MajorTopicYN="N">Viral pandemic</Keyword>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>04</Month>
<Day>28</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2020</Year>
<Month>06</Month>
<Day>23</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>07</Month>
<Day>06</Day>
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<Month>7</Month>
<Day>31</Day>
<Hour>6</Hour>
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</record>

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   |wiki=    Sante
   |area=    CovidSeniorV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:32729548
   |texte=   Real-time diagnosis of reactive oxygen species (ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic.
}}

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	Serveur d'exploration sur la COVID chez les séniors
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Serveur d'exploration sur la COVID chez les séniors

Real-time diagnosis of reactive oxygen species (ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic.

Real-time diagnosis of reactive oxygen species (ROS) in fresh sputum by electrochemical tracing; correlation between COVID-19 and viral-induced ROS in lung/respiratory epithelium during this pandemic.

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